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| Protective Effects of Vitamin A on Paracetamol-Induced Hepatotoxicity in Rats |
Amna Abdallah Ali, Mohammed Ahmed Abdalla, Omer Mohamed Abdalla
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Abstract:
Paracetamol which is widely used as anti-inflammatory drug and pain killer is known to cause liver injury. Vitamins A and E are among the antioxidants vitamins that have attracted the attention of biochemical and toxicological researchers in the recent times as vitamin A is reported to enhance a marked reduction in CCl-induced hepatic damage, this study was aiming to investigate the hepatoprotective effect of vitamin A (retinol) against paracetamol-induced toxicity in Wister rats. Five groups of rats were used in a seven days experiment; The control group received no treatment, the negative control grouphas received single dose of PCM (1000mg/kg, orally) on day7and groups 3, 4, and 5 received oral doses of vitamin A of 100IU/kg, 500IU/kg, and 1000 IU/kg, respectively for 7 days and in the last day (7thday) they received a single dose of PCM of 1000mg/kg/orally. Animals were sacrificed in day 8 and blood samples were collected and used for analysis of ALT, AST, albumin, total protein, cholesterol, triacylglycerides and total bilirubin. The group of rats used as negative control showed significant elevation in serum ALT, AST, cholesterol and bilirubin levels when compared with the control group. A dose of 1000 IU/kg vitamin A has showed protective effects against PCM induced hepatotoxicity.
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