International Journal of Academic Health and Medical Research (IJAHMR)   Year: 2019 | Volume: 3 | Issue: 8 | Page No.: 8-12 Leptin Level in Obese Diabetic Women in Wad Madani, Sudan Aliya Elamin Mohammed, Mohammed Yousief Sukkar and Azhari Mohammed Hamid Abstract: Obesity is considered a major public health problem associated with changes of leptin as appetite-regulating hormones. High-calorie diet, together with low physical activity has resulted in obesity and diabetes being serious social problems. To evaluate the level of leptin hormone and it is association with obesity, fat distribution and type 2 diabetes (T2D). The study comprised 150 women divided into 3 groups according to BMI value I (normal body weight), II (overweight) and III (obese diabetic). Plasma concentrations of Leptin were determined by sandwich enzyme-linked immunoassay.leptin concentration was found to be significantly higher in group II and III than in group recommendations: Serum leptin levels are higher in the Sudanese obese diabetic group and correlate positively with obesity which seems to be an important link between obesity and T2D. Future studies for illustrating the connection between genetic mutations affecting leptin regulation and obesity is tremendously needed to focus the issue at molecular level and fill gaps regarding obesity thrilling and therapeutics.