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| Evaluation of Coagulation Profiles (PT, INR, and APTT) among Sudanese Patients with Falciparum Malaria Infection |
Zainab Omer Mohammed, Khansaa Mohammed Gaberallah, Mai Shakir Mohammed; ,Khalid Abdelsamea Mohamedahmed
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Abstract:
Background: Malaria remains the one of major health problems globally with increased morbidity and mortality, especially P. falciparum that can cause various complications involving various systems of the body and complications. Coagulopathy is one of these complications. Objectives: The study aimed to evaluate the coagulation profiles (PT, INR, and APTT) among patients with falciparum malaria infection. Methodology: A case-control laboratory-based study was conducted in Wad Medani Teaching Hospital, Gezira State, Sudan among 200 subjects (100 patients with falciparum malaria [mean age 20.96 ± 17.65 years; 36% male] and 100 as healthy control [mean age 21.62 ± 12.79 years; 49% male]) in the period from November 2017 to August 2018. 1.8 ml of venous blood was collected. The degree of parasitemia was determined directly from thick blood film. The platelet-poor plasma was obtained by centrifugation of blood at 1200 - 2000 rpm for 15minutes. PT, INR, and APTT were measured by using Coatron M4 coagulometer. SPSS software (V 20.0) was used for data analysis. Results: 61 patients (61%) had high PT level where 39 patients (39%) had normal PT with a mean (15.8 ± 1.82 sec); while 77 patients (77%) had high INR compared to 23 patients (23%) had normal INR with a mean (1.19 ± 0.22). Furthermore, 74 patients (74%) had a normal APTT compared to 26 patients (26%) with prolonged APTT, with a mean (37.9 ± 4.67 sec). Significant results in the PT, INR, and APTT in falciparum malaria patients were detected when compared with control (P-value = 0.000, 0.000, and 0.000 respectively). Conclusion: Falciparum malaria causes significant derangement in the coagulation process (intrinsic, extrinsic, and common pathways) so causes prolongation of PT, INR, and APTT. So evaluation of coagulation profiles may be helpful in the management and outcome of patients.
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