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| In Vitro Study of Antibacterial Activity of Many Topical Creams Marketed In Gaza Strip |
Akram Atallah, Ismail Mezher, Elham Abuwakeed, Nahed Hegazy, Amjad El-Shanti
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Abstract:
Bacterial Superficial skin infections are often treated with topical antibiotic preparations applied directly to the skin which offer a useful alternative to oral and parenteral agents in some conditions and have many advantages such as easy to use, lower side effects, higher drug concentrations in the site of infection, lower risk of developing bacterial resistance and more economical than other routes. Recently, many strategies have been proposed to conflict bacterial resistance. Combination therapy and using novel drug delivery systems are the main approaches in this field. A large number of antibacterial topical skin preparations currently available in Gaza markets which manufactured by different pharmaceutical companies. Some of these preparations are pharmaceutical alternatives which contain the same therapeutic moiety but differ in salt or ester form, in the dosage form or in the strength. In this study we evaluated the antibacterial activity of four types of antibiotic creams used widely in Gaza dermatological clinics, fusidic acid, silver sulfadiazine, gentamicin and clindamycin. For this purpose, in vitro disk diffusion method, which is one of the most widely used antimicrobial susceptibility testing methods in routine clinical laboratories, was used to examine antibacterial activity of these topical preparations as described by EUCAST. Furthermore, we prepared a combination of different used antibiotic creams and examined the antibacterial activity of these combinations.
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