International Journal of Academic Health and Medical Research (IJAHMR)   Year: 2020 | Volume: 4 | Issue: 12 | Page No.: 4-10 Assessment of Anti-Myeloperoxidase Antibodies, Cholesterol and LDL-C in Serum of Sudanese Patients with Systemic Lupus Erythematosus: A pilot study Nosiba Abd Algader Altahir, Mariam Abbas Ibrahim, Salma H Elhassan , Altaf Suleman Mosad.and Nuha Eljailli Abubaker Abstract: Background: Immunological dysfunction, especially the secreation of antinuclear antibodies (ANA) are main feature of the Systemic lupus erythematosis (SLE) disease. Increased atherosclerosis in patients with SLE due to oxidative stress anti myeloperoxidase antibodies. Aim: This study aims to assess serum anti-myeloperoxidase antibodies, cholesterol and LDL-C levels in Sudanese Patients with Systemic lupus erythematous (SLE) in Khartoum State. Materials and methods: This cross-sectional study was conducted in Military Hospital, in Khartoum State (Sudan),. Fifty Sudanese Patients with SLE and fifty healthy individual were enrolled in this study. The anti-Myeloperoxidase antibodies was measured by cobas and the levels of serum cholesterol and LDL-C were measured by using Mandray. Results: The result found that,62% of patients at age less than 40 years , 86% of patients were females, 10% of patients were exposed to sun, while 90% of patients were not exposed to sun, 6% of patients had current medication and 20 % had chronic medication. The result of serum anti-myeloperoxidase antibodies (MPO) among study groups showed that, 18% of patients had positive result, while 82% of patients had negative result.100% of control had negative result. There was significant increased in LDL- C level in patients with SLE compared to control group , while there was insignificant different in cholesterol level in both study group. The odds ratios of cholesterol, and LDL-C levels and duration of disease among patients group were 0.5 and 0.6 respectively (P =0.05). The result showed that, 54% of patients had duration of disease more than 5 years. Conclusion: This study concluded; anti-MPO antibodies are found in patients with SLE, the level of LDL-C is elevated in patients with SLE.