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| Determination of D-dimer Levels among Sudanese Patients with Rheumatoid Arthritis |
Abdalraheem Ali Babikr, Yusria Yousif Mohammed, Souad Fadlalla Ali , Albadawi Abdelbagi Talha, Khalid Abdelsamea Mohamedahmed
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Abstract:
Rheumatoid arthritis is long lasting autoimmune disorder that primarily affects the joints and results in warm, swollen, and painful joints. This is a hospital based case-control study conducted in Wad Medani Teaching Hospital, Gezira State, Sudan from May to November 2018 on 50 cases (68% female; 32% male) and 50 normal healthy controls. The study aimed to determinate the levels of D-dimer in patients with rheumatoid arthritis. 2.5 ml venous blood was collected in tri sodium citrate anticoagulant. Platelet poor plasma was prepared by centrifugation of citrated blood at 2500 rpm for 15 minutes. D-dimer level was measured using sandwich immune-detection method. The results showed the level of D-Dimer was found to be normal in 31 (62%) of patients compared to 19 (38%) was high. A significant increase in the D-dimer level (mean: 512.08 ±278.55 ng/ml) in patients with rheumatoid arthritis were detected when compared with normal healthy control (mean: 281.44±84.44 ng/ml) (P value = 0.000). The study concluded that there was elevation level of D-dimer in patients with rheumatoid arthritis disease.
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