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| Congenital and Obstructive Heart Defects: A Systematic Review and Meta-Analysis |
Rizwan Jamil, Humza Anwar, Hafiz Muhammad Sufyan
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Abstract:
Congenital heart defects (CHDs) are the most usually happening birth imperfection and most cases have no known reason. There is considerable proof to propose hereditary danger factors assume an unmistakable part in CHD improvement and numerous examinations have been fruitful distinguishing CNVs related with CHD hazard. Tragically, CNVs hazard factors are frequently uncommon and only from time to time repeated across various investigations. To deliberately audit distributed examinations directed to distinguish the relationship between duplicate number variations and non-syndromic congenital heart defects in populace considers. For our deliberate audit, we utilized three information bases to distinguish up-and-comer articles: PubMed, Web of Science and Cochrane Database of Systematic Reviews. We looked for all investigations distributed through November 21th, 2019 and aggregated elite of extraordinary examinations for assessment. Every information base was looked for contemplates containing at any rate one of the chose congenital heart deformity terms and one duplicate number variation term. The quest uncovered 1,893 one of a kind articles for audit. Our essential consideration measures were case-control or case-information base investigations of duplicate number variation hazard factors for non-syndromic congenital heart defects. Contextual investigations, case arrangement, family-based examinations were taken out from thought. Studies assessing syndromic CHD were prohibited. Approaches that assessed the predominance of a particular pathogenic CNV and were not essentially purposed for CNV disclosure were barred. A sum of 1,893 exceptional articles were at first arranged dependent on incorporation and rejection measures by auther. Articles meeting the consideration rules were fundamentally evaluated and incorporated for introduction. After investigation, 36 examinations were distinguished that met the consideration models and 27 were remembered for the quantitative survey.
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