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| The Impact of Total PSA Value on Diagnosis of Prostate Diseases in Sudanese Patient |
Ahmed Ibn Edriss Mohamed , Mohamed El Imam , El Jaily Mohamed Abuagla M. Dafalla
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Abstract:
Introduction: Measuring total serum PSA levels is currently the mainstay of prostate cancer detection and many studies have shown that patients with prostate cancer have in general high levels of serum PSA. The commonly cut-off point used for PSA is 4 ng/mL. Aim: The aim of this study was to determine the sensitivity and specificity of the total PSA in the diagnosis of prostate cancer also to determine its significance in diagnosis of benign prostate hyperplasia. Material and methods: By reviewing the medical records, clinical and laboratory information of 250 cases are collected from the archives of the El-Rahmma diagnostic center Khartoum North Sudan. Statistical analysis of the obtained data was done by IBM SPSS advanced statistics version 22 (SPSS Inc., Chicago, IL). Analysis of the ROC (receiver operating curve) was used to determine the sensitivity and specificity. Results: 41 % of adenocarcinomas are seen between 61 to 70 years old. Gleason score grade group 3 is the most commonly diagnosed (28%), Gleason's score grade group is not statistically dependent on age at diagnosis P value (0.786). Serum tPSA with a cut-off of 4 ng/mL had 99% sensitivity and 7% specificity, statistically it is not significant for prostate cancer P.value (0.367). Conclusion: Total PSA was relatively significant in detection of prostate cancer and should not be used alone as a guideline without DRE. Prostatectomy should not be performed before histopathological diagnosis when the level of tPSA was above 2 ng/ml.
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