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| Assessment of Glucosylated Hemoglobin, Glucose and Body Mass Index in Sudanese Women with Polycystic Ovarian Syndrome in Khartoum State |
Lamia Hasaballah Osman Ali , Nuha Eljailli Abubaker and Seif eldeen Ahmed Mohamed
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Abstract:
Back ground: Polycystic ovary syndrome (PCOS) is endocrine disorders in women of reproductive age. Characterized by metabolic abnormality and a wide spectrum of clinical features such as, obesity, menstrual abnormalities and hyperandrogenism. Objectives: The aim of this study was to assess the levels of Random blood glucose (RBS) and HbA1c among Sudanese Women with poly cystic ovary syndrome (PCOS). Methods: Analytical case control, hospital based study was conducted from March to April 2018, involving fifty Sudanese women who had been diagnosed with polycystic ovary syndrome, chosen from Omdurman Maternal Hospital, in Khartoum State, like cases, fifty age-matched healthy women were recruited as controls. The ages from 20 to 41 years).Blood samples were collected and the levels of RBS and HbA1c were measured, using atomic absorption spectrophotometer (BUCK SCINTIFIC 210/211 VGP VER3.94C). Data analysis was carried out, using SPSS version, 21. Mean values were calculated and independent t-test was used to compare mean values in case versus the control group. Pearson's correlation was used to find the relationship between RBS, HbA1c and age. Results: The result showed that, 60% of patients at age range between 20-30 years, while 40% of patients at age range between 31-41 years. The result found 20% of patients over weight, 22% obese, while 58% had normal weight. There was significant increase in the mean levels of RBS, HbA1c and BMI in women with PCOS, compared to control groups. The mean ± SD: (101.2±18.19 versus 86.24±12.05,p- value = 0.000) for RBS, (5.20±0.59 versus 4.80±0.37 , p- value =0.000) for HbA1c , (25.33±4.67 versus 22.09±3.52 , p- value= 0.037) for BMI. There were no correlation between HbA1c, RBS and age in women with polycystic ovary syndrome (r= 0.162, p- value=0.260) (r=0.190,p- value=0. 187) respectively. There were no correlation between HbA1c, RBS and BMI (r=0.089, p- value = 0.540)(r= 0.041, p-value= 0.777) respectively. Conclusion: The levels of RBS and HbA1c were increased in Women with PCOS compared to healthy women.
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