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| NanoCalc Simulation and Modellings of Silver Nanoparticles for direct Antimicrobial Coatings |
Olabimtan Olabode H., Ochigbo Victor, Ashade Noah O.
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Abstract:
Bacterial infections, especially by antimicrobial resistant (AMR) bacteria, are increasing problems worldwide. AMR is especially a problem with health care-associated infections due to bacteria in hospital environments being easily transferred from patient to patient and from patient to environment, and thus, solutions to prevent bacterial transmission are needed. Hand washing is an effective tool for preventing bacterial infections, but other approaches such as nanoparticle-coated surfaces are also needed. In this study, android based nanoparticles application was direct simulated and modelled to the advantage of silver nanoparticle antimicrobial coated surfaces. The nanoparticles with possible precursors on the basis of their diameter (nm), initial concentration (uM) and volume (ml) between 1 to 10 in each cases modelled respectively against the average and total surface areas in nm2, average and total volume in nm3, average mass in gram, dosage in ug/ml and final concentrations in uM. The graphical models between the average Ag NP diameter with the average surface area [ y=0.8527x0.25 [x ×1015] ( R2=1)]; average volume [y=1.2425x0.333 (R2=1)], mass [y=5.6682x0.3333 [x×10-18] (R2=1)]; total surface area [y= 0.8527x0.25[x×10-18](R2=1)], total volume [y=0.7947x0.2 (R2=1)], dosage [y=0.7414x0.25 (R2=1)] and final concentration [y=0.3632x0.2603 (R2=0.9398)]. Between the initial concentration and average surface area [y=0.5637x0.5002 (R2=1)], average volume[y=1.2425x0.333 (R2=1)],mass[y=5.6682x0.3333 (R2=1)], total surface area[y=0.8527x0.25[x×1015] (R2=1)], total volume[y=0.7947x0.2[x×1014] (R2=1)], dosage [y=0.7414x0.25 (R2=1)] and final concentration [y=0.3632x0.2603 (R2=0.9398)] and with initial aqueous volume against the average surface area [y=0.5637x0.5002 (R2=1)], average volume [y=1.2425x0.333 (R2=1)], mass [y=5.6682x0.3333[x×10-18] (R2=1)], total surface area[y=0.8527x0.25[x×1015] (R2=1)], total volume[y=0.7947x0.2 [x×1014](R2=1)], dosage[y=0.7414x0.25 (R2=1)] and final concentration [y=0.3632x0.2603 (R2=0.9398)].Preparation of silver coated antimicrobial coatings on solid surfaces and many other application can be systematically achieved with this simple and user friendly applications. However, further validation and claim are necessary for wide applications and acceptance.
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