Abstract:
This is a descriptive retrospective case aimed to detect CK5/6 expression in bladder tumors using immunohistochemistry. Forty paraffin embedded blocks were randomly selected from patients samples previously diagnosed as bladder tumors Samples (30 samples were malignant tumors (28 samples were transitional cell carcinoma and 2 samples were adenocarcinoma) and 10 samples were benign). The paraffin blocks were cut by rotary microtome and stained by immunohistochemical method for detection of CK5/6. The data obtained was analyzed using SPSS program. The patient's age ranged between 49 and 70 years with mean age of 59 years, most patients were more than 55 years representing 22(55 %) and the remaining 18(45%) patients were less than 55 years. Immunohistochemical expression of CK5/6 was revealed positive result in 20/30 samples and negative result in 10/30 samples in malignant tumors, while all benign tumors showed positive result for CK5/6 (10/10), with significant statistical association between CK5/6 expression and histopathology diagnosis of bladder tumors (P < 0.05). This study concludes that CK5/6 expression is associated with benign forms of bladder tumors.
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