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| Morphological Changes and Cellular Proliferation in Epithelial Oral Mucosa among Children Streets Chloroprene Users, Sudan |
Abdalraheem Ali Babiker, Akrum Salah
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Abstract:
: Chloroprene is polymerized to form polychloroprene (neoprene), a synthetic rubber used for wire and cable covers, gaskets, automotive parts, adhesives, caulks, flame-resistant or high gum strength cushioning and other applications requiring chemical, oil and weather rubber(1).This case control study was conducted in Gezira State Wad Madani from December 2016 - October 2017, to assess the cytological atypia and agyrophilic nucleolar organizer regions Count in Epithelial Oral mucosa exposed to chloroprene among Sudanese users. Fifty individuals were chloroprene addicted as cases, and fifty individual as control, their age ranged between (11-43) years with a mean age (17.4) years. The samples were prepared and stained by Papanicolaou stain and silver stain. The result revealed that epithelial atypia in 46% by Papanicolaou stain. The mean agyrophilic nucleolar organizer regions increased in 62% of studied population. There was strong association between duration of chloroprene ues and severity of cytological atypia, and increase mean agyrophilic nucleolar organizer regions with p.value (0.000) for both. The amount of chloroprene use was positively correlated with increase mean agyrophilic nucleolar organizer regions with p.value (0.000). The study conclude that chloroprene is one of the risk factors for change normal epithelial to abnormal. Chloroprene users should undergo continuous screening program. Oral exfoliative cytology is a simple, non-invasive technique, cytological analysis of exfoliated cells should be done for screening and regular follow up of premalignantlesions.
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