Title: Detection of Cyclin D1 Immunohistochemical Expression among Sudanese Patients with Colorectal Cancer
Authors: Hanaa Ibrahim Salih Mohammed, M.Sc , Mohammed Abdelgader Elsheikh, P.hD , Alkhair Abd Almahmoud Idris, Ph.D
Volume: 5
Issue: 11
Pages: 22-31
Publication Date: 2021/11/28
Abstract:
Objectives: This study was aimed to evaluate the prognostic value of cyclin D1 in colorectal cancer and to correlate cyclin D1 expression with the different clinicopathological parameters. Methods: Tissues microarray paraffin block with 48 colorectal cancer samples were retrieved from the archives of Elrahma Medical Center. The immunostaining of cyclin D1 was performed and analyzed. Results: Cyclin D1 did not show association with clinicopathological features. There was no statistically significant correlation between Cyclin D1 immunoexpression and tumor grade, with p value > 0.05 that's considered as statistically insignificant. Conclusion: Our study indicated that; cyclin D1 immunoexpression cannot be used as a predictor of survival in colorectal cancer. It also showed no significant correlation with clinicopathological features.