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| Comparison between Centrifugation and Apheresis Methods of Platelet Concentrate Preparation |
Mojahid Siddig Ibrahim, Ahmed Salah Mohamed, Qusai Hamid, May Mohammed Ali, Ahmed Elhadi
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Abstract:
Achieving a rich platelet concentrate (PC) from blood donation procedure remains a great challenge in blood banking practice. Two preparation methods with variable efficiency exists, which are blood unit centrifugation and apheresis. The aim of this study was to compare between centrifugation and apheresis methods of platelet units' preparation. A total of 90 Platelets donors attending the blood bank of Khartoum oncology hospital during June 2019 were enrolled for this study. Body weight, height in addition to Hematocrit and platelets count were measured for all participants before donation. PC was prepared by centrifugation from 60 donors, collected into bags containing citrate and nutrient phosphate and dextrose (CPD), while the rest 30 donors were subjected for platelet apheresis (Trima accel) and PC units were collected into bags containing Acid citrate dextrose (ACD). Platelets count was performed on samples from PC units using fully automated haematology analyzer (Sysmex KX-21N, Japan). Data were analyzed by statistical package for social science (SPSS) program. Results showed no statistically significant difference in Platelets count before donation between the two study groups (p. value = 0.289). While Platelets count was significantly different between samples of PCs of the two preparation methods (p. value = 0.002). For PC using aphersis, the Platelets count of the unit was significantly predicted by a model consisting of donors Platelets count, Hematocrit, body weight and height (p. value < 0.05). Among the covariates used in the model, donor's Hematocrit was the strongest predictor of Platelets count in the PC.
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