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| Assessment of Plasma Protein C Level among Sudanese Children with Sickle Cell Anemia |
Tibyan A. Mustafa. Rayan G. Abdelnabi. Mohamed A. Omer, May Mohamed Ali and Ahmed Elhadi
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Abstract:
Protein C (PC) deficiency has been reported in sickle cell anemia (SCA) and postulated to contribute to the pathogenesis as well as clinical manifestations of the disease. However, there is paucity of data on PC level in Sudanese children with SCA. This is a case control study conducted in Jafar Ibn Auf Pediatric Hospital, Khartoum-Sudan during the period from February 2019 to May 2019.A total of 100 Sudanese children were enrolled for this study, 50 SCA children as cases group and 50 apparently healthy children as control group who were matched with cases in regards to age and gender. PC level was tested by (AESKULISA) assay Kit and measured by ELISA (Human Reader, HS). The results showed that, mean PC level in cases was (79.71±11.97) which is significantly lower than in controls (84.38±10.37) (p. value = 0.039). Moreover, PC level showed significant differences between study groups according to the history of blood transfusion, thrombotic event and anti-thrombotic therapy of patients (p. values = 0.006, 0.019 and 0.019 respectively). On the other hand, no significant differences of PC level were observed between males and females (p. value = 0.78). In addition, a significant positive correlation was observed between the age of patient and PC level (p. value = 0.010, R = 0.359). In conclusion, children of SCA had lower PC level compared with healthy subjects. Those children need to be investigated for PC level in their early stage of the disease in order to minimize the risk of hypercoagulability.
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