International Journal of Academic Health and Medical Research (IJAHMR)   Year: 2021 | Volume: 5 | Issue: 7 | Page No.: 1-6 Lymphomatous Turn during Gougerot Sjogren Syndrome Mimicking Breast Cancer: A Case Report M. BOUSLIKHANE, GHDAIF.S, A. ASSAL, H. BOUFETTAL, S.MAHDAOUI, N.SAMOUH Abstract: Gougerot sjogren syndrome is a mild, slowly progressive autoimmune disease associated with low morbidity and mortality, characterized primarily by organ-specific autoimmune manifestations and systemic manifestations. Indeed, these complications, feared during the evolution, have been known and reported for many years. This risk of non-hodgkin lymphoma is, moreover, notably greater during primary Gougerot sjogren syndrome than during any other autoimmune pathology. The most commonly affected tissue is the exocrine salivary glands, but other tissues may be involved: stomach, nasopharynx, skin, liver, kidney, lung, breast. In both models, primary Sj?gren's syndrome non-Hodgkin's lymphoma or chronic viral hepatitis infection, autoreactive B lymphocytes with rheumatoid factor activity continuously stimulated by the autoimmune process are particularly exposed to clonal transformation by a second oncogenic event.