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| Assessment of Serum Ferritin Level among Chronic Renal Failure Patients Subjected to Frequent Hemodialysis and Blood Transfusions |
Raga A. M. Ali, Sebah M. A. Mohammed, Zuliekha A. Idriss , May Mohammed Ali, Ahmed Elhadi.
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Abstract:
Anemia due to blood loss during hemodialysis is commonly encountered in patients of chronic renal failure. It is managed with frequent blood transfusions that may accompanied by iron over load. The present study aimed to assess serum Ferritin level among chronic renal failure patients with frequent blood transfusions. This was a case control study conducted in Sudanese Kidney Transplanted Association Hospital in Khartoum-Sudan during the period from November 2018 to February 2019. A total of 50 participants were enrolled for this study consisting of 25 patients undergoing regular hemodialysis and received multiple blood transfusions and 25 matched patients under hemodialysis but without blood transfusions. Serum Ferritin was measured using fully automated chemistry analyzer Cobas(r)-e411. Data were analyzed using Statistical Package for Social Sciences (SPSS) version 16.0. Mean serum Ferritin level of patients under hem-dialysis and regular blood transfusion was significantly increased compared to those under hem-dialysis without blood transfusion (p. value = 0.0000). Moreover, serum Ferritin level showed significant positive correlation with the number of blood units transfused (p. value = 0.000, r = 0.855). At the other hand, no significant differences in serum Ferritin level between the study groups according to age and gender of the patients (p. values = 0,285 and 0.353 respectively). Patients of chronic renal failure under frequent hemodialysis and blood transfusions are prone to iron overload.
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