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| The expression of Vascular Endothelial Growth Factor (VEGF) and Ki67 in Correlation to Stage of Breast Cancer |
Mohammed Ismail Idreis Adam, M.Sc , Alkhair Abd Almahmoud Idris, P.hD and Mohamed Abdelgader Elsheikh, P.hD
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Abstract:
Background: Breast cancer (BC) is a common malignant neoplasm comprising a large heterogeneous group of cancers with variable histological type, biological and clinical characteristics. Aim: This study was aimed to detect over expression of vascular endothelial growth factor and Ki67 in correlation to stage of breast cancer. Materials and Methods: This was descriptive cross sectional hospital based study conducted in Radiation &Isotopes -Center of Khartoum (RICK). Included Sudanese women with breast cancer during the period between (October 2020 To January 2021). Purposive sampling techniques was used in this study included 50 subject, from each tissue sample paraffin block was prepared two paraffin sections it was cut into 3µm thickness section floated into preheated floating water bath at 40?c, two sections were placed in coated glass slide for Immunohistochemistry, one section was placed in clean microscopical slide for Hematoxylin and Eosin , incubated in oven at 58?c. Results: The study results revealed that expression of VEGF in invasive ductal carcinoma was showed positive staining reaction in 14 cases (28%). No expression of VEGF was reported in 4 cases of stage I, in 7 out of 32 cases of stage II, and in all 7 cases out of 7 of stage III .There was significant positive correlation between VEGF expression and the stage of tumor (p value <0.000), and a higher proportion of cases were found in stage II and III. There was significant positive correlation between VEGF expression and Ki67(p value <0.000). Conclusion: This study concluded that there was relationship between VEGF expression and cancer stage and Ki67 expression. Recommendations: The study recommends that further study with more sample size is required.
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