International Journal of Academic Health and Medical Research (IJAHMR)   Year: 2021 | Volume: 5 | Issue: 9 | Page No.: 29-31 Immunoexpression of Vascular Endothelial Growth Factor among Sudanese Patients with Bladder Cancer Changjowk Peter Lai AKER, M.Sc, Mohammed Abdelgader Elsheikh MOHAMMED, P.hD, Elsadig Ahmed ADAM, MD, Alkhair Abd Almahmoud Idris, P.hD Abstract: BACKGROUND: Vascular endothelial growth factor (VEGF) is a signaling protein which is important for formation of the circulatory system and growth of blood vessels from pre-existing vasculature. Cancers that can express VEGF are able to grow and metastasize, because many solid cancers require an adequate blood supply to grow beyond the limited size. Aim: To determine the Immunoexpression of Vascular Endothelial Growth Factor among Sudanese Patients with Bladder Cancer. METHODOLOGY: This was an analytical cross-sectional study, included forty patients with (TCC); study patients from different Histopathology laboratories in Khartoum state- Sudan, VEGF was detected by using IHC method. RESULTS: VEGF immunoexpression was reported positive in 20 out of 40 patients (50%), the study conducted that; there was an association of VEGF immunoexpression and higher tumor grade of (TCC) as the frequency of VEGF expression was 16 out of 27 patients (59.2%) with high grade, while the frequency of VEGF expression was 4 out of 13 patients of low grade (30.8%) P value = 0.010. CONCLUSSION: according to obtained results we concluded that; the, there was a significant association between VEGF and bad prognosis of (TCC).