Abstract:
Neuroendocrine carcinomas mainly affect the respiratory system and the gastrointestinal tract. Breast localization is rarer, from 0.3% to 5% depending on the series. The first case was described in 1977 by Cubilla and Woodruff. It is defined by the expression of neuroendocrine markers, the most widely used of which are chromogranin A and synaptophysin, at more than 50%. The World Health Organization (WHO) classification of breast cancer, published in 2003, first recognized neuroendocrine mammary carcinoma as a separate histological entity. This classification was updated in the fourth edition of 2012. Three main histological types have been described: well differentiated neuroendocrine mammary carcinoma, poorly differentiated small cell neuroendocrine carcinoma and invasive breast carcinoma with neuroendocrine differentiation. Reporting to us the case of a 67-year-old multiparous postmenopausal diabetic patient undergoing treatment, Admitted for CEP of an SD nodule discovered on autopalpation, in which clinical examination found a right breast nodule clinically classified CT2N0Mx Radiologically corresponds to a tissue mass of the JQINF measuring 8mm, near the submammary fold classified ACR4c. The anatomopathological and immunohistochemical study of the microbiopsy of the breast is in favor of a poorly differentiated carcinomatous process, the morphology of which is in favor of a neuroendocrine mammary carcinoma Primary neuroendocrine mammary carcinoma is a little-known histological form on all aspects: clinical presentation, radiological, histological characteristics, treatment and survival. The diagnosis may be missed because the search for neuroendocrine markers is not systematic. Furthermore, the differential diagnosis with a secondary breast location of a neuroendocrine tumor can be difficult, hence the importance of a systematic work-up looking for primary extramammary cancer. Treatment is similar to invasive ductal mammary carcinoma. Survival is found to be good, nevertheless the data in the literature are conflicting.
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