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| Antibacterial Activity of Nickel Nanoparticle from Calotropis Procera and Its Green Synthesis
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Abideen, A. Adekanmi, Owolabi, Oluwafemi Akinkunmi, Ifeoluwa, David Ajewole, Lawal , Ibraheem Kehinde, Oyero, Gbenga Micheal, Olasunkanmi Busayo Tomi
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Abstract:
Antimicrobial drugs are a necessary element of daily living, but they are frequently misused by consumers. This, combined with microbes' innate ability to build resistance mechanisms quickly, has resulted in the creation and spread of multidrug-resistant pathogenic diseases. As a result, there is a critical need for innovative antimicrobial scaffolding to overcome these microorganisms' resistance. Nanotechnology has opened up new possibilities for the development of novel or enhanced antibacterial chemicals. The antibacterial activity of nickel nanoparticles synthesized from Calotropis procera is investigated in this study. The leaves of the Calotropis procera (Sodom apple) were collected in Agric Oke Osun, Osogbo, Osun State, Nigeria. Calotropis procera (Sodom apple) leaves were cleaned well and incised into small pieces with distilled-deionized water. Using a conventional process, a nickel nanoparticle was made from Sodom apple leaf extract. Scanning Electron Microscopy (SEM) was used to characterize the nanoparticle, which was made using a drop casting approach. The antibacterial properties of nickel nanoparticles and Sodom apple leaf extract were tested using Agar well diffusion methods against Staphylococcus aureus and Pseudomonas aeruginosa. The characterization of produced nanoparticles revealed that some particles have a rod shape and others have a hexagonal shape, which is the ideal morphology for nickel nanoparticles. For nickel nanoparticles, the maximum zone of inhibition was discovered against Pseudomonas aeruginosa (6mm) and the lowest degree of antibacterial activity was recorded against Staphylococcus aureus (2mm). The zone of inhibition of Calotropis procera leaf extract against Staphylococcus aureus and Pseudomonas aeruginosa was measured at 2 mm and 4 mm. The produced nanoparticles exhibited a broad antimicrobial susceptibility range, indicating that they might be used as promising antimicrobial agents in the pharmaceutical industry to control pathogenic germs.
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