International Journal of Academic Health and Medical Research (IJAHMR)   Year: 2022 | Volume: 6 | Issue: 4 | Page No.: 45-48 Eosinophilic Variant Of Acute Myelomonocytic Leukemia Revealed By Necrotizing Myocarditis : Case Report. Download PDF Moumni Mohamed Bilal, Samouche Mouna, Tlamçani Imane, Amrani Hassani Moncef Abstract: Acute myeloid leukemia are a heterogeneous group of hematological malignancies that account for more than 80% of acute adult leukemia, with a worldwide incidence rate of 2.6 per 100.000 population. The myelomonocytic subtype with eosinophilic component accounts for 5 to 8% of these acute myeloid leukemias and can occur at any age, but especially in young adults. It is associated with chromosome 16 inversion. Inaugural cardiac involvement during these hemopathies is rare, and seems to be related to eosinophilia associated with AML4 vEo. We report a case of acute necrotizing myocarditis revealing acute hypereosinophilic eosinophilic myelomonocytic leukemia in a young patient with congestive heart failure, in the absence of progressive coronary or valvular disease. The biological assessment, myelogram and molecular biology have allowed to diagnose acute myelomonocytic leukemia with eosinophilic variant, and to establish a rapid and effective therapeutic management.