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| Family Forms Of Chronic Intestinal Inflammatory Diseases According To A Moroccan Context
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A. Maktoub, H. Abid, A. Attar, N. Lahmidani, M. El yousfi, D. Benajah, A. Ibrahimi, M. El Abkari
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Abstract:
Introduction: The familial aggregation of Chronic Inflammatory Bowel Disease (IBD) is the result of an interaction of shared environmental factors and genetic susceptibility. For most authors, 8-10% of subjects with Crohn's disease (CD) and 6% with ulcerative colitis (UC) have one or more parents, regardless of family relationship. (1) with lower percentages in the Asian population (2-3). The objective of our work is to study the type, severity, extent, treatment modalities, course and prognosis of the disease in this group of patients. Result: we collected 55 cases of familial forms of IBD, that is 6% of all patients followed for IBD, including 35 cases of CD (63,6 %) and 20 cases (36,3%) of UC. For both UC and Crhon's disease, the disease onset age was 27.3 years old on average with extremes ranging from 16 to 56 years old. Relatives were first-degree in 90% and 80% of UC and Crohn's disease cases, respectively. UC cases: the location was pancolitis in 12 cases (60%). Relatives also had UC in 12 cases (60%). 25 % of patients were put on immunosuppressants. None of our patients required surgery. CD cases: It is an ileocolic form in 17 cases (48,5 %) and a colonic form in 7 cases (20 %). 18 patients required immunosuppressants during follow-up (51,4%), 48,57% needed a needed a second line of therapy, 12 patients were operated (34,2%). Relatives had CD in 48,55% of cases (n = 17). Conclusion: The prevalence of familial UC and CD in our study was close to the literature, and the family history did not show any predictive value for phenotype, course, and disease outcome
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