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| Challenges Parents Face in Adopting Hydroxyurea Treatment to improving the health of Children with Sickle Cell Disease: A Systematic Review
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Khalil Alnakhli - BS and Dr. Bruce Lazar, MBA, DM
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Abstract:
Hydroxyurea therapy improves the life quality of sickle-cell children by reducing hospitalization, blood transfusions, and pain, although acceptance rates among parents remain low. This review purposed to highlight the challenges parents face in adopting hydroxyurea treatment for their sickle cell children. The findings will forge a way to improve care for the sick who need therapeutic interventions. This systematic literature review identified keywords that it searched in the PubMed and Online Wiley Library databases while adopting the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines. The researchers assessed 21 articles to identify the factors that impede parents from adopting hydroxyurea treatments. The review yielded eight themes that included the drug's safety profile, treatment's effectiveness, side effects, cost, therapy's availability, lack of guidelines, lack of knowledge, and ineffective decision-making techniques. The findings indicated the challenges the parents face in adopting hydroxyurea treatment, which provides relevant evidence that will guide the formulation of a solution to curb the hesitance. The study implies that health Informatics and professionals in the field can address the parents' challenges in adopting hydroxyurea treatment for their sickle cell children by identifying solvable impeding factors.
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