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| Antifungal Susceptibility Pattern of Candida species among Female Patients Attending Murtala Mohammed Specialist Hospital Kano, Nigeria
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Aisha Abba Habib; Musa Ahmed Abubakar, Umar Sani Dorayi
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Abstract:
Antifungal drugs such as Clotrimazole, Itraconazole, Ketoconazole and Fluconazole are the main drugs of choice being used in the treatment of candidiasis at contemporary level. The present study was conducted with the aim of isolating Candida species and determining their susceptibility pattern against selected antifungal drugs. High clinical vaginal swabs were the specimens used for isolation of Candida species. 150 specimens from both symptomatic and asymptomatic female patients of suspected vulvovaginal candidiasis (VVC) were collected and subjected to culture followed by microscopy analysis. 39 samples were found positive on culture out of which, only 24 were Gram positive for Candida species recording to about 61.54%. The disc diffusion method was employed for the determination of susceptibility of Candida species against the antifungal drugs. Highest susceptibility was observed with Fluconazole, followed by Ketoconazole, and then Itraconazole. The least sensitivity was observed with Clotrimazole, and the sensitivity was found to be more effective at 30 µm/disc concentration. Thus, the susceptibility of the fungal isolates was dose dependent. However, the susceptibility results showed that there is emerging fungal resistance to azoles, and Fluconazole is still the most effective and drug of choice in the management of vulvovaginal candidiasis.
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