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| The Effectiveness of Barr Body in the Determination of Females Sex
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Rania M. SidAhmed, Snaa A. Mahjoob, Hanaa A. Al-oufi, Maha G. Al-mutairi, Deemah A. Al-sedrani, Yazi F. Al-dhafeeri, Manar S. AL-dhafeeri , Mariam K. Alenzi and Wjdan K. Al-khaldi
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Abstract:
Medical Genetic is the branch of medicine that involves the diagnosis and management of hereditary disorders. This includes studies of inheritance, mapping disease genes, diagnosis and treatment, and genetic counseling. Demonstration of nuclear sex play initial role in sexing of the individual. Barr body is condensation of chromatin present at the nuclear of cell in female individuals. The objectives is to evaluate the reliability of blood film smear barr bodies for sex determination and to find out the percentage of the positive and negative cases. This was retrospective and prospective study to evaluate the efficiency of barr Body in blood smear for determination of female sex. Including 32 female blood film samples stained by Giemsa stain and diagnosed according to criteria of Barr body identification. Laboratory analysis of the result reveal that the positive were 84.4 %, negative samples were 15.6 %, the sensitivity was 96 % and specificity was 55 %. Regarding our results that the barr body blood film is highly sensitive that can be used as diagnostic method for different purpose such as sex determination in forensic medicine, and in rapid diagnosis of sex for urgent cases, but this method was less specific. Therefore we recommended using of barr body blood film as diagnostic method but can be confirmed by more modified method. Also giemsa stain can be modified to be more specific for barr body determination.
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