Title: Tea Seed Oil Alleviates Cardiovascular and Hepatic Complications in L-NAME-Induced Hypertensive Rats
Authors: Lateef Eugene Yahaya
Jamiu Folorunsho Atanda
Ademola Adetokunbo Oyagbemi
Volume: 7
Issue: 12
Pages: 181-188
Publication Date: 2023/12/28
Abstract:
This study investigated the therapeutic potential of Tea (Camellia sinensis) seed oil (TSO) in mitigating hypertension induced by NG-nitro-L-arginine methyl ester (L-NAME) in rats. Forty male Wistar albino rats were divided into five groups, each consisting of eight rats, and subjected to different oral administrations. Group A, designated as the control, received 5 ml/kg of normal saline while groups B-E received 40 mg/kg L-NAME. Additionally, groups C and D received 0.45 and 0.6 ml/kg of TSO, respectively, and group E received the standard drug Enalapril Maleate at 2 mg/kg. These administrations were conducted once daily and extended over a 28-day period. Various parameters, including blood pressure indices, serum lipid profile, serum liver enzyme levels, oxidative stress, and antioxidant enzyme activities in heart and liver tissues, were assessed. The results reveal that TSO administration attenuated L-NAME-induced alterations in blood pressure parameters. TSO also exhibited efficacy in restoring disrupted lipid parameters and reducing elevated liver enzyme activities, demonstrating its potential in ameliorating hyperlipidemia and exerting hepatoprotective effects. Additionally, TSO showed antioxidant properties by decreasing malondialdehyde levels and potentiating the activities of catalase (CAT), superoxide dismutase (SOD), glutathione peroxidase (GPx), and reduced glutathione (GSH) in heart and liver tissues. These findings collectively suggest the therapeutic potential of TSO in alleviating hypertension-related cardiovascular and hepatic complications through its vasodilatory and antioxidant properties.