International Journal of Academic Health and Medical Research (IJAHMR)   Year: 2023 | Volume: 7 | Issue: 2 | Page No.: 163-167 Premature Ovarian Insufficiency Download PDF Sanae Stimou, Hafsa Taheri, Hanane Saadią and Ahmed Mimouni Abstract: Premature ovarian insufficiency (POI) is defined as amenorrhea of more than six months before the age of 40 with an elevated follicle stimulating hormone (FSH) level and low estradiol on at least two separate samples taken a few weeks apart. Its prevalence is 1/10,000 in women under 20 years of age, 1/1,000 in women under 30 years of age and 2 - 4% in women under 40 years of age. It is clinically manifested by impuberism and/or primary or secondary amenorrhea. Apart from iatrogenic causes (radiation or chemotherapy, surgery), the most frequent causes are genetic or chromosomal, such as Turner syndrome and fragile X syndrome. Despite investigations aimed at etiology, premature ovarian failure remains unexplained in about 70% of cases, especially in cases of secondary amenorrhea. Management of patients is aimed at avoiding cardiovascular and bone complications secondary to hypoestrogenism. It involves hormone replacement therapy with a combination of 17 ? estradiol and progesterone or an estroprogestogenic pill. Spontaneous fertility is 3 to 10%.