International Journal of Academic Health and Medical Research (IJAHMR)   Year: 2023 | Volume: 7 | Issue: 2 | Page No.: 191-197 The Application of CA 125 in the Diagnosis and Follow up of Ovarian Cancer Download PDF Randa E. Mohammed, Rania M. SidAhmed, Ahmed M. Alhaj Abstract: Ovarian cancer represents the sixth most commonly diagnosed cancer among women in the world, and causes more deaths per year than any other cancer of the female reproductive system. Despite the high incidence and mortality rates, the etiology of this disease is poorly understood. The main objective of this study is to detect the relation of CA 125 levels with the diagnosis and follow up of ovarian cancer patients, and to access its role in the diagnosis and follow up of ovarian cancer in Sudanese patients. Ovarian cancer Samples were examined for the socio-demographic characteristics, histological and cytological features and the CA 125 levels, which was measured from the serum of ovarian cancer patients using Electrochemilminescence techniques by Roche Cobs e 411 instrument. Laboratory analysis of selected 124 ovarian cancer samples showed the following: CA125 level elevated (more than 35U/ml) in 94 samples (75.8%) in the first reading of CA125 (before treatment), in the second sample (after treatment) showed increasing of CA125 level in 74 samples (59.68%), and the third sample (after treatment) showed increase of CA125 in 54 (43.55%), this result showed gradual reduction in CA125 levels from first reading, to second , and to third, in which the first samples mean was 1160_1837, second samples mean was 510_930 and the means of third samples was 94_167. In conclusion CA125 levels elevated in ovarian cancer patients (75.8%) and these levels decreased with the ongoing therapy, which is important in the follow up of patients. The study recommended the using of CA125 in diagnosis and follow-up of ovarian cancer patients. Further studies should be done using large sample size.