Abstract:
This study aimed to detect Interleukin-1? (IL-1?) and their associated level factors in Sudanese patients infected with Schistosoma mansoni. A cross-sectional study was conducted in New Halfa City-Eastern Sudan during the period from March to October 2011. Participants in this study included 305, 177 were males (45 were positive and 132 were negative) and 128 were females (65 were positive and 63 were negative). Faeces samples were collected from all the subjects included in the study and examined by using direct wet mount and Kato-Katz technique. Also, serum samples were collected from all subjects and examined by using the Th1/Th2/Th9/Th17/Th22 13plex Kit FlowCytomix (eBioscience) technique. The results showed that S. mansoni-infected individuals have differences in their levels of IL-1? when was compared in two groups, p=0.0279 and in three groups, p=0.009. Also, when was compared infected with uninfected p=0.001. Currently S. mansoni-infected individuals have more IL-1? than uninfected. The relation between the mean of IL-1? and the gender was significant (p value was less than 0.05, p=0.000). The relation between the mean of IL-1? and age-groups was significant (p value was less than 0.05, p=0.000). The relation between the mean of IL-1? and intensity of S. mansoni infection was significant (p value was less than 0.05, p=0.000) while the correlation was positive (r=0.759). The relation between the mean of IL-1? and Kato technique was significant (p value was less than 0.05, p=0.000). The relation between the mean of IL-1? and treatment was significant (p value was less than 0.05, p=0.000). The results obtained from the current study showed that the relation between the mean of IL-1? and the tribes was insignificant (p value was more than 0.05, p=1.000).
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