Title: Assessment of Dyslipidemia among Hemodialysis Patients in Western Libya
Authors: Mohamed Daw Said, Ashraf Mohamed Albakoush, Azab Elsayed Azab
Volume: 8
Issue: 12
Pages: 11-17
Publication Date: 2024/12/28
Abstract:
Background: Chronic kidney disease (CKD) causes irreversible damage to the renal tissue resulting in decreased kidney function. It is known more for its morbidity than for its mortality as the deranged kidney functioning affects almost every organ system of the body. Dyslipidemia is one of the most common complications of chronic renal failure (CRF) reflected even in the early stages of CRF and usually parallels the deterioration in renal function. As a consequence, dyslipidemia as a risk factor in CKD progression should be explored and documented more. Objectives: The aim of the study was to evaluate the alterations of lipid profile in CKD patients on hemodialysis in western Libya. Methodology: This is a cross-sectional observational study conducted in Nephrology clinic and hemodialysis ward at Surman and Sabratha hospitals Libya, between February to May 2024, after considering inclusion and exclusion criteria. The lipid profile of 103 eligible participant was analyzed using an auto analyzer. After generation of the proper template, data was entered in Microsoft Excel (Microsoft Corp., Redmond, Washington, United States) and analysis was done through SPSS Version 27. Results: In this study, CKD patients showed significantly lower levels of total cholesterol(TC), High Density Lipoprotein (HDL), and Low Density lipoprotein (LDL) in all CKD patients compared to healthy controls (p-value for each parameter <0.001). On the other hand, there is no significant difference in triglyceride levels. Regarding to gender differences in CKD and healthy controls, Females had higher levels of cholesterol, triglycerides, and LDL. However, In healthy individuals: Males had higher levels of cholesterol, triglycerides, and LDL; females had higher HDL. Conclusions: Kidney patients exhibit a distinct lipid profile characterized by lower total cholesterol, HDL, and LDL levels compared to healthy individuals. This pattern suggests altered lipid metabolism in kidney disease.