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| Predictive factors for the development of diabetes in Psoriatic Arthritis
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H.Arrech ¹, I.El Mezouar ¹, O.Idrissi ouali ¹, N.Akasbi ¹, N.Bahra ², T.Harzy ¹
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Abstract:
Introduction: Psoriatic arthritis (PsA), a chronic inflammatory rheumatic disease, affects both genders, leading to joint symptoms, skin manifestations, and various concurrent medical conditions. Diabetes is a prevalent and variable comorbidity in PsA, with inflammatory mechanisms contributing to cardiovascular diseases, highlighting the need for systematic screening and management of comorbidities in PsA. The objective of our study focuses on assessing the prevalence of diabetes in PsA and identifying associated factors. Materials and Methods: This study is retrospective in nature, focusing on a cohort of individuals diagnosed with psoriatic arthritis based on the Classification Criteria for Psoriatic Arthritis (CASPAR) from the year 2006.These individuals were followed and managed between January 2011 and February 2023. Clinical, biological, and radiographic data were collected. Results: Our study encompassed a cohort of 99 individuals diagnosed with PsA. The average age of these patients was 55.16 years, with a standard deviation of ±14.9 years. The male-to-female sex ratio was 0.41. The average disease duration was 7.56 years +/- 8.8. Diabetes was present in 17.2% of the patients. Our study finds that diabetes was more common in patients who had hypertension (p=0.003), patients with dyslipidemia (p=0.002), those with a personal history of cutaneous psoriasis (p=0.03), patients with a total hip replacement (PTH) (p=0.04), and menopausal patients (p=0.004). Additionally, the mean vitamin D levels were higher in diabetic patients compared to the non-diabetic group. This difference is statistically significant with p=0.04.Hypertension (HTA) and anti-citrullinated protein antibodies (ACPA) were significantly associated with diabetes in the context of PsA. Conclusion: our study identified HTA, ACPA, dyslipidemia, menopause, and a personal history of cutaneous psoriasis as predictive factors for the development of diabetes in PsA.
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