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| Presentation, management and outcome of 13 patients with pregnancy-associated breast cancer: a case series
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J.El Haoudani, N.Edith Ngalande,Y. Belhaj, FZ. fdili alaoui ,S. jayi, My abdelilah melhouf et, H. Chaara
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Abstract:
Background: Cancer is the 2nd cause of death among women aged 25 to 44 (2), which makes the association of cancer and pregnancy possible purely by chance. Breast cancer associated with pregnancy (PABC) is a complication found around 1 in 10 000 to 1 per 3,000 pregnancies. It is one of the most common cancers associated with pregnancy (3) this case series aims to study the presentation management and prognosis of pregnancy-related breast cancer. Patients and methods: Data concerning patients' and tumors' characteristics, management, delivery and maternal outcome were recorded from institutional electronic database. In this case series we collected data from PABC patients treated at the UTH Hassan II fez Morocco, between January 2016 to April 2022. The key recommendations on managing such patients are summarized. Results: The histological type was found on invasive ductal carcinoma, in 92,3% cases. The ACR classification was performed in 13 patients: ACR 0 in 1 patient (8%), ACR 4 in 4 patients (31%) and ACR 5 in 8 patients (61).Therapeutically, 69.23% of the patients were treated with the Patey procedure. Chemotherapy was administered in 11 patients. 8 patients received neoadjuvant chemotherapy 72.72%, including 4 patients who were pregnant, only 2 patients. Received adjuvant chemotherapy 18.18%, and only 1 patient received palliative chemotherapy 9.09 Conclusions: Women with pregnancy associated breast cancer should be managed like non-pregnant breast cancer patients and should expect a similar outcome, without causing harm to the unborn child. To achieve a good outcome in pregnancy associated breast cancer, a multidisciplinary approach is mandatory. Pregnancy-related breast cancer tends to be diagnosed in an advanced stage with poor prognosis. Any breast abnormalities observed in this period should alert clinicians, and a meticulous radiological evaluation is mandatory. The early diagnosis of this disease would increase the chances of successful treatment.
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