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| Predictive factors for survival of lung cancer patients after radiotherapy
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Ayoub El massnaoui, Karima Sammoud, Soukaina Morchid, Sami Amraoui, Ouafae Mersseti, Nabila Sellal, Adil najdi, Mohamed El hfid
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Abstract:
Background: Lung cancer remains one of the leading causes of cancer-related death worldwide, particularly in advanced stages, underscoring the importance of effective treatment strategies. Radiotherapy plays a crucial role in the treatment of lung cancer, either alone or in combination with other modalities. The aim of our work is to identify predictive factors for survival after radiotherapy, which is essential to optimize patient outcomes. Methods: We conducted a 5-year retrospective cohort study at the Tangier Oncology Center, including patients diagnosed with lung cancer who underwent radiotherapy. Results: Ninety-seven patients were included, with a male/female sex ratio of 7.81 and a mean age of 59.8 years (± 9.2). Univariate analysis revealed associations indicating that smoking, disease progression, and type of palliative radiotherapy were associated with poor prognosis, whereas type of curative radiotherapy and high dose radiation were associated with good prognosis. Multivariate analysis confirmed that smoking was associated with an unfavorable outcome (OR: 4.73, 95% CI: 1.15-19.46, p < 0.031), whereas curative radiotherapy was associated with a favorable outcome (OR: 0.22, 95% CI: 0.06-0.75, p < 0.016). In the five-year survival analysis, we found a survival probability of 30.6% among patients, with a median survival time of 16 months (95% CI: [ 5.44 - 26.55]. Conclusion: In conclusion, our findings underscore the multifaceted nature of lung cancer prognosis and response to treatment after radiotherapy. The association between smoking and adverse outcomes highlights the critical importance of smoking cessation interventions in lung cancer management. Conversely, the favorable prognosis associated with curative radiotherapy emphasizes the importance of aggressive treatment approaches.
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