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| Nonparametric Estimation of Type 1 Cencored Survival and Hazard Functions in Leukemia Cancer Patients with Kaplan-Meier Method
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Evi Wijayawati, Alda Fauziah Afifah, Michelle Adelia Suwarno, Toha Saifudin
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Abstract:
Health is one of the basic necessities for the life of the elderly (lansia). Health development is also one of the goals in the Sustainable Development Goals (SDGs), precisely the third goal, namely ensuring a healthy life and promoting the well-being of all ages. In this goal, the SDGs have set several targets that must be achieved by each country. Cancer is currently still one of the world's biggest health problems. Cancer is a disease caused by the abnormal growth of cells in a particular organ, which can cause clinical symptoms for the sufferer. Based on data from the World Health Organization (WHO) in 2015, cancer is the second leading cause of death after cardiovascular disease, causing 8.8 million deaths. To date, the exact cause of leukemia is unknown, but there are predisposing factors that cause leukemia, such as genetic factors; certain viruses cause changes in gene structure (Tcell Leukemia-Lhymphoma Virus/HLTV), radiation, immunosuppressive drugs, cardiogenic drugs such as diethylstilbestrol, hereditary factors; in monozygotic twins, chromosomal abnormalities; down syndrome. Leukemia usually affects white blood cells. In this healing process, one of the methods used is placebo treatment. Based on this, in this study, the probability of survival and the risk of death of placebo method recipients up to a certain time limit will be estimated using the Kaplan-Meier statistical method. Result of the discussion the chance of life for patients receiving placebo treatment for the first week after placebo treatment is 95.2% with a decrease for the next time interval until the 25th week showing a constant chance of 18.9% until the last observation week.
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