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| Hematological Parameters Alterations and Its Relationship with Cardiovascular Diseases Risk Factors among Type II Diabetes Mellitus Patients in Western Libya
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Mohamed Omar Albasha, Azab Elsayed Azab, Hayfa M. A. Abdullah, and Abdulali K. A.Taweel
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Abstract:
Background: Diabetes is a metabolic disorder characterized by hyperglycemia with impaired insulin secretion or a variable degree of insulin resistance. its complications are a major and growing public health problem around the world, involvement in a developing country like Libya. Dyslipidemia and derangement in various hematological parameters were observed among diabetes mellitus patients. Objectives: The study aimed to evaluate the alterations of haematological parameters, and find the correlation between fasting blood sugar (FBS), and Hemoglobin A1c (HbA1c) with body mass index (BMI), lipid profile, and haematological parameters among type 2 diabetes mellitus patients. Methods: The present study was conducted on 220 type 2 DM patients, attending Sabratha Teaching Hospital and Surman General Hospital for a routine health check-up and 110 normal healthy subjects without diabetes or any other diseases. All the participants were aged between 30-70 years. A blood sample of 5 ml was drawn by venous puncture from each participant. Blood samples were used for determination of CBC, HbA1c, levels of FBS, serum cholesterol, TG, HDL-C, LDL-C, and VLDL-C. Data were analyzed by independent t-test, chi-square Fisher exact test using the Statistical Package for the Social Sciences (SPSS) program for Windows, Version 25. Results: The results showed RBCs, and Platelets counts, Hb, and Hct were decreased significantly (P<0.01), while WBCs count, PDW and MPV were increased in diabetic patients compared with the healthy individual group. The mean FBS level and HbA1C value, the serum levels of cholesterol, triglycerides, LDL-C, VLDL-C, and LDL/HDL ratio were significantly (P?0.01) increased, whereas the serum levels of HDL-C was significantly (P?0.01) decreased in diabetic patients when compared with the controls. Conclusion: The results showed the diabetic patients had hyperglycemia, increased of HbA1C, dyslipidemia, and disturbance in haematological parameters. Further studies are needed to confirm these results.
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