|
|
| |
| Frequency of BRCA1 rs799917 polymorphism in ovarian cancer patients attending NCI, Gazira state - Sudan
Download PDF
|
Alaa Mubarak Ahmed ELbasheer, Adil Mergani Babikir Hassan, Ibrahim Bakeet Yousif Elemam, Yousif Abdelhameed Mohammed, Randa alginad Mohamed
|
Abstract:
Ovarian cancer is eighth most common cancer in women globally. BRCA1 and BRCA2 genes are the two most common genes in autosomal dominant and high penetrance form of breast cancer and ovarian cancer. There are no studies in Sudan that specifically address BRCA1 and BRCA2 mutations in ovarian cancer patients, and despite the disease's importance for public health, the country lacks precise national epidemiologic data on it. The aim of the study evaluate the frequency of ( rs799917) polymorphisms ( In this study determine of one BRCA1 known mutations ( rs799917 ) in Sudanese women patients with ovarian cancer because suspect effect on risk of cancer) . we conducted a case-control population study and spotted that occurrence of rs799917-BRCA1 to evaluate the BRCA1 polymorphisms and genetic susceptibility of ovarian cancer among Sudanese women in Gezira state. All cases Ovarian cancer patients attending National Cancer Institute. For control sample take from normal women do not suffer from any type of cancer and she does not have any family history of cancer, Majority of the ovarian cancer patients were in the age group of <50 years. For all sample case and control make DNA extraction , PCR - PIRA method and gel electrophoresis , to give perfect result. In our study revealed that rs 799917 could related with ovarian cancer risk among Sudanese populations. We concluded BRCA1 mutations SNPs rs799917 in Sudanese ovarian cancer women showed high risk wth ovarian cancer. More studies in this mutation by high sample size and search in other mutations suspected of ovarian cancer to determine the effect of Association between genetic variants and ovarian cancer risk
|
|
|
| | |