Title: Infiltrating lobular carcinoma of the breast: About 40 cases
Authors: Douzi Najoua, Erraghay sanae, Mamouni Nisrine, Bouchikhi Chahrazad, Banani Abdelaziz
Volume: 8
Issue: 8
Pages: 88-98
Publication Date: 2024/08/28
Abstract:
Lobular breast carcinoma is a distinct clinicopathological entity which represents 10 to 15% of infiltrating breast carcinomas and constitutes the second type of invasive breast cancer after invasive ductal carcinoma (1 ;2). It is a cancer whose diagnosis is difficult, often bilateral, multicentric or multifocal. The objective of our study is to evaluate the epidemiological particularities, clinicopathological aspects, diagnostic difficulties as well as the treatment and prognosis of lobular carcinoma. This is a retrospective study of 40 cases of infiltrative lobular carcinoma carried out in the obstetrics and gynecology department I of the Hassan II university hospital center in Fes, over a period of 6 years spread from January 2016 to December 2022. The age range of our series was between 34 and 79 years, with a mean age of 55.4 years, the discovery of a breast nodule on self-palpation was the most common reason for consultation, tumors classified as T2 were the most frequent (70% of cases), bilaterality was observed in 2 patients. Mammography coupled with ultrasound was performed in all our patients, magnetic resonance imaging was lacking in 7 of our patients. Two patients had metastases at the time of diagnosis. Radical Patey surgery was performed immediately in 82.5% of cases. Neoadjuvant chemotherapy was indicated in 30% of cases, adjuvant chemotherapy in 37.5% of cases, palliative chemotherapy was indicated in metastatic cases. Radiotherapy was performed in 65% of cases, hormonal therapy in 85% of cases, and targeted therapy in 15% of cases. The evolution was marked by the appearance of metastases in 5 cases including 3 deaths. In conclusion, lobular breast carcinoma is a rare entity with a particular profile; its diagnosis can pose certain difficulties. Currently its treatment does not differ from that of infiltrating ductal carcinoma.