Title: Profil des anticorps anti-nucléaires dans la sclérodermie systémique: Une étude rétrospective de 33 cas
Authors: Mohammed OUBOKS, Imane AFIF, Ouahiba BHALLIL
Volume: 8
Issue: 8
Pages: 131-135
Publication Date: 2024/08/28
Abstract:
Introduction: Systemic scleroderma (SSc) is a rare autoimmune disorder. The complex pathophysiology of this disease is responsible for great clinical polymorphism, with the production of a wide range of autoantibodies. Most of these autoantibodies are anti-nuclear antibodies (ANA). These are of great diagnostic and prognostic interest. The aim of this study is to describe the profile of ANA in patients with SSc. Materials and methods: This was a retrospective descriptive study including thirty-three patients with SSc referred to the Immunology Laboratory for the detection of NAA. Screening for these antibodies was performed using indirect immunofluorescence (IFI). If positive, this was followed by identification of the antigenic targets using the Immunodot or ELISA technique, depending on the IFI results. Results: Thirty-three patients with SSc were identified. The mean age in our series was 48 years. The sex ratio F/M was 5.55. NAA positivity was 96.7%. Fourteen patients had positive anti-Scl70 antibodies, a prevalence of 42.42%. Anti-CENP-A and B antibodies were positive in 12.12% and 24.24% respectively, and anti-RNA polymerase III in 12% of cases. The prevalence of anti-PM-Scl75, anti-PM-Scl100 and anti-SSB was 18%, 15% and 3% respectively. Conclusion: The profile of NAAs in SSc in our series is marked by the predominance of anti-Scl70 antibodies and anti-CENP-A and B antibodies, which is consistent with the data in the literature.