Title: Investigation of antimicrobial resistance patterns and measurement of Interleukin 23 among children with otitis media
Authors: Assistant professor Dr. Sanaa Khudhur Jameel
Volume: 9
Issue: 1
Pages: 71-79
Publication Date: 2025/01/28
Abstract:
Otitis media is the predominant disease that infects children. The bacterial agents, antibacterial resistance patterns, and assessment of interleukin 23 serum levels are necessary to reach the specific treatment media among children.This research included 50 children who suffer from otitis media. Isolation and identification of bacteria, then sensitivity testing was conducted by the Vitek 2 system. Serum samples were collected for assessment of the IL-23 level by using ELISA and compared with 50 healthy children. Gram-negative bacteria were the most prevalent, represented by Pseudomonas aeruginosa (30%), while Gram-positive bacteria were Streptococcus pneumomiae (10%). Regarding levofloxacin and Meropenem, all bacteria isolates showed high susceptibility. Comparing the patients' serum levels to those of the control group, the present study revealed an elevation in IL-23 compared to the control group.The current study showed that a major indicator for the diagnosis of otitis media was IL-23, and the all pathogenic bacteria express high sensitive to levofloxacin and Meropenem, and showed multidrug resistance to the other used of the antibiotics.