Title: Emerging Electronics-Based Cancer Treatment Approaches: A Critical Review
Authors: Gabriel Ebiowei Moses, Dr Preye David Ogbe, David Ebregbe
Volume: 9
Issue: 10
Pages: 16-26
Publication Date: 2025/10/28
Abstract:
Emerging electronics-based cancer treatment approaches represent a transformative shift in oncology, moving beyond conventional thermal ablation toward precision bioelectronic modulation of tumor biology. Techniques such as Tumor Treating Fields (TTFields), Cold Atmospheric Plasma (CAP), Photodynamic Therapy (PDT), and advanced non-invasive electromagnetic and electrochemical strategies harness electric fields, plasma-generated reactive species, and light-activated molecular pathways to selectively target cancer cells while minimizing collateral damage to healthy tissue. These modalities are not only designed to induce apoptosis and disrupt cancer cell proliferation but also show promising potential in reprogramming the tumor microenvironment and enhancing anti-tumor immune responses. Compared to traditional radiofrequency and microwave ablation, which rely on heat-induced necrosis, next-generation electronic therapies offer improved precision, reduced invasiveness, and compatibility with combination treatments such as immunotherapy and drug delivery systems. As clinical translation progresses, these technologies are redefining the landscape of cancer therapy by integrating physics-based interventions with biological signaling control, signaling a new era of non-thermal, immune-supportive, and patient-tailored cancer treatment.