Title: The Contribution of Platelet CD40L (CD154) to the Activation of Proinflammatory and Procoagulant Pathways in Atherogenesis
Authors: Ruziyev Zarif Muxammadovich https://orcid.org/---
Volume: 9
Issue: 10
Pages: 46-51
Publication Date: 2025/10/28
Abstract:
Platelet activation, a key component of hemostasis, also plays a crucial role in the pathogenesis of atherosclerosis through modulation of inflammatory and procoagulant processes. One of the central molecular mediators of these effects is CD40L (CD154), expressed on platelets and released in a soluble form. This review summarizes current literature regarding the role of platelet-derived CD40L in the initiation and maintenance of inflammation, endothelial activation, platelet-leukocyte aggregate formation, as well as in the activation of procoagulant pathways and stabilization of thrombotic structures. Special attention is given to signaling mechanisms (TRAF, MAPK, and others), interactions with CD40 on various vascular wall cells and integrin receptors, and the prospects for targeted therapeutic interventions. Summary tables of key findings and schematic representations of molecular interactions are provided. The review also discusses limitations of current approaches and outlines directions for future research.