Title: Release Of Cd40l Upon Platelet Activation As A Key Nexus Linking Thrombosis And Inflammation. Literature Review
Authors: Ruziyev Zarif Muxammadovich
Volume: 9
Issue: 11
Pages: 56-61
Publication Date: 2025/11/28
Abstract:
Platelets, traditionally viewed as mediators of hemostasis and thrombosis, are increasingly recognized as active participants in inflammation and immunity. A central molecular link between platelet activation and inflammatory signaling is the rapid mobilization and shedding of CD40 ligand (CD40L, also known as CD154). Upon platelet activation, membrane-bound CD40L is translocated from ?-granule stores to the platelet surface and then cleaved to generate soluble CD40L (sCD40L). This released CD40L can bind to a variety of receptors on endothelial cells, leukocytes, and even platelets themselves, triggering proinflammatory responses, leukocyte recruitment, and further platelet activation. In this review, we survey the literature on the mechanisms of CD40L release from platelets, the downstream signaling pathways and cellular targets, and the evidence linking CD40L to thromboinflammatory pathologies. We also discuss conceptual models that place platelet CD40L release as a "bridge" between thrombosis and inflammation. We propose a unified framework and highlight gaps for future investigation.