Title: Impact of Iraqi Date Palm Extracts on Acute Renal Injury Induced by Amikacin in Rat
Authors: Duha. Zaidoon. Al-Basiri . Ausama. Ayob. Jaccob . Muhsin.Sagir.Ghalib.AL-Moziel . Sabaa.Ali.Mohammed.AL-Fadal
Volume: 9
Issue: 3
Pages: 41-52
Publication Date: 2025/03/28
Abstract:
Amikacin one of the most potent aminoglycoside-antibiotic, treats gram-negative bacterial life-threatening conditions. Nowadays it has been associated with acute renal toxicity which can result in serious damaging effects on the renal tissue related to oxidative stress, inflammation, and kidney function alteration. This experiment evaluates the protective effects of Iraqi date palm extracts against amikacin's toxic effects. Methods: A total of 35 adult male rats are classified into 5 groups each one including 7 members treated for 10 days as follows: normal control received 1mL/kg of D.W through oral gavage tube, Date extract group received 500mg/kg from both date cultivars(Barhi & Bream) through oral gavage tube, negative control group received 1mL/kg of D.W through oral gavage tube, Barhi date extract group received 500mg/kg from Barhi extract through oral gavage tube, bream date extract group received 500mg/kg from bream extract through oral gavage tube, on day 7 all group administered 1.2g/kg from I.P. amikacin except normal control and date extract group, to induce acute renal injury. All animals were sacrificed and kidneys were removed for further investigation. Results: the resulting data reflected the protection effect of Iraqi date palm extracts to ward off the toxic impact of amikacin, there is a significant improvement in renal functions and reduced the damaging amikacin effect on the renal tissue. Conclusion: Iraqi date palm extracts are a good candidate for alleviating the harmful effects of amikacin due to their potential antioxidant capacity.