Title: Syndrome de Sharp : Intérêt des anticorps anti-ribonucléoprotéines
Authors: Ouboks Mohammed -, Lahdili Mustapha -, Afif Imane -, Kaaouch Hanae -, Bhallil Ouahiba -
Volume: 9
Issue: 3
Pages: 107-113
Publication Date: 2025/03/28
Abstract:
L Introduction : Sharp's syndrome or mixed connective tissue disease is a rare autoimmune disorder characterised by the presence of Raynaud's phenomenon, the positivity of antibodies specific for a ribonucleoprotein (RNP) antigen and various clinical manifestations which overlap with those of other connective tissue diseases such as lupus, systemic scleroderma (SSc), myositis and rheumatoid arthritis (RA). The aim of our study is to describe the relevance of anti-ribonucleoprotein antibodies in Sharp syndrome. Materials and methods : This is a retrospective descriptive study spread over a period of 3 years and 6 months carried out in the Immunology Department of the HASSAN II University Hospital in Fez. Sharp's syndrome was diagnosed according to the criteria proposed by Alarcon-Segovia. Results : Patients ranged in age from 25 to 83 years. Females were most affected (72.72%) with a sex ratio M/F of 0.37. Clinical symptoms were dominated by chronic arthralgias (63.63%), associated with other clinical and biological signs. The anti-RNP antibody was found in all patients included in our series. Discussion and conclusion : Sharp's syndrome remains a rare connective tissue disease. Anti-RNP antibodies were positive in all cases. These autoantibodies are important tools in the diagnosis and prognosis of this disease.