Title: Integrating Ultrasmall Superparamagnetic Iron Oxide in Diagnostic Imaging and Radiotherapy for Enhanced Tumor Targeting
Authors: Ashraq Taima Atwan, Basim A. Almayahi
Volume: 9
Issue: 5
Pages: 387-392
Publication Date: 2025/05/28
Abstract:
Ultrasmall superparamagnetic iron oxide nanoparticles (USPIOs) are gaining recognition as multifunctional agents in cancer theranostics due to their unique magnetic properties and biocompatibility. This review evaluates the integration of USPIOs in magnetic resonance imaging (MRI) and radiotherapy, focusing on their role in enhancing tumor specificity and therapeutic efficiency. Recent literature highlights the superior contrast enhancement provided by USPIOs in MRI, enabling improved tumor characterization and delineation. Additionally, USPIOs enhance radiosensitivity through the generation of reactive oxygen species (ROS), making them valuable for image-guided radiotherapy (IGRT). Functionalization strategies allow for targeted tumor delivery, while preclinical studies and ongoing clinical trials support their efficacy. Overall, USPIOs represent a promising advancement in cancer diagnosis and treatment, with future research aimed at optimizing their use and addressing safety considerations.