Title: Activation of the CD147 Signaling Pathway by Platelets Promotes the Proinflammatory Phenotype of Monocytes in Rheumatoid Arthritis
Authors: Ruziyev Zarif Muxammadovich
Volume: 9
Issue: 7
Pages: 1-3
Publication Date: 2025/07/28
Abstract:
Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by joint inflammation and damage. Recent studies have highlighted the crucial role of platelets in the pathogenesis of RA through their interaction with immune cells and contribution to inflammatory processes. In this study, we investigated the role of the surface protein CD147 on platelets in inducing a proinflammatory monocyte phenotype in RA. We found that platelet–monocyte interactions mediated by CD147 lead to phenotypic changes in monocytes, particularly within the CD14++CD16+CCR2+ (Mon2) subset, which is associated with increased production of proinflammatory cytokines and activation of transcription factors such as NF-?B. These findings underscore the important role of platelets in shaping the inflammatory response in RA and propose CD147 as a potential therapeutic target for novel treatment strategies.