Title: Detection of Anti-Nuclear Antibody in Patients with Acute Kidney Injury Attending Gezira Hospital for Renal Disease and Surgery, Sudan (2022)
Authors: Mustafa Ibrahim Abbas, Muaz Khalid Ahmed, Khalid Abdelsamea Mohamedahmed,, Albadawi Abdebagi Talha, Abdelrahman Eldaw Mohammed
Volume: 9
Issue: 7
Pages: 4-9
Publication Date: 2025/07/28
Abstract:
Introduction: Acute kidney injury (AKI) is a common and serious clinical syndrome with diverse etiologies, including possible autoimmune mechanisms. Anti-nuclear antibodies (ANA) are hallmark biomarkers of systemic autoimmunity and may indicate underlying autoimmune pathology in AKI patients. Anti-Nuclear Antibodies (ANA) are found in many disorders, as well as some healthy individuals. Aim: The aim of the study was to detect Anti-Nuclear Antibodies in patients with acute kidney injury. Methodology: This was a case-control study conducted at Gezira Hospital for Renal Disease and Surgery from February to October 2022. A total of 60 blood samples were collected from participants with different ages and both sexes (40 samples from patients as cases and 20 from healthy controls). Antinuclear antibodies were tested by ELISA. Data were analyzed by statistical package for social sciences program (SPSS version 22). Results: Comparing the means of Anti-Nuclear Antibody between cases and controls showed significant differences (P value = 0.048) with an increase in patients more than healthy people. A significant difference also occurred in some other parameters such as hemoglobin, total white blood cells, urea, and creatinine (P value = 0.001, 0.004, 0.000, 0.000 respectively). Additionally, ANA test comparing with gender and age groups showed no significant differences (0.989, 0.935, 0.074 respectively). Concussion: ANA titers were elevated in AKI patients in compare with healthy control group. The detection of ANA test should be done as a routine confirmatory test for patients attending the hospital.