Title: Coagulation Abnormalities in Diabetic Patients with Retinopathy among Sudanese Patients in Cairo City -eygpt-2025
Authors: Amal Mustafa , Moram Osman , Maab Mohammed , Marafi abdalrazig , Lana Ahmed and Tarig A. M. Hamid
Volume: 9
Issue: 7
Pages: 32-38
Publication Date: 2025/07/28
Abstract:
Background: Diabetes considered as one of the common diseases and one of the causes of death and disability worldwide Diabetes a heterogeneous group of diseases, characterized by a state of chronic hyperglycemia, caused by a variety of etiologies and genetic and environmental factors acting in concert. Methodology: This was prospective case-control study. Performed in 78 blood samples, of which 38 were collected from diabetic patients with retinopathy and 40 from healthy individual's to evaluate prothrombin time, activated partial thromboplastin time, Platelet count and platelet indices in diabetic patient with retinopathy. The statistical analysis was conducted using SPSS 26 computer program Data were analyzed using a T-test to compare variables, with P < 0.05 considered statistically significant. Results: the results showed that 42% males and 58% females. The participants' ages ranged from 17 to 72 years, with a mean of 33.28 ± 13.97 years. Hemostatic parameters measured included prothrombin time (PT) with a mean of 14.12 ± 2.15 seconds, activated partial thromboplastin time (APTT) with a mean of 38.47 ± 5.58 seconds, platelet count (PLT) averaging 276.54 ± 73.62 x10^3/?L, platelet distribution width (PDW) at 13.16 ± 3.28, mean platelet volume (MPV) at 9.58 ± 1.10 fL, and plateletcrit (PCT) averaging 0.26 ± 0.06. The study sample was divided into case (n=38) and control (n=40) groups, revealing significant differences between groups in PT, APTT, and PLT (p < 0.05), while MPV showed no significant difference (p = 0.447). Gender-based analysis within the case group showed no significant differences in PT, APTT, PLT, or MPV (p > 0.05). Moreover, no significant correlations were found between duration or age and the clinical parameters in the case group (p > 0.05).