Title: Adult Granulosa Cell Tumors of the Ovary: Diagnostic Challenges and Report of Two Rare Cases.
Authors: Salma Messoussi, Hala Bennani, Chadia Khelloufi, Saad Benkirane
Volume: 9
Issue: 8
Pages: 87-90
Publication Date: 2025/08/28
Abstract:
Adult-type granulosa cell tumors (AGCTs) are a rare subtype of ovarian cancer that occur primarily in perimenopausal and postmenopausal women, accounting for 2 to 4% of all ovarian cancers. They are characterized by a long natural history and a tendency to recur several years after the initial diagnosis. These tumors present with atypical symptoms due to estradiol secretion, which can make diagnosis challenging. Surgery is the cornerstone treatment for ovarian AGCTs. while adjuvant therapies such as chemotherapy, radiotherapy, and hormonal treatments are reserved for advanced or recurrent cases. We report two cases of adult granulosa cell tumors with atypical clinical presentations, highlighting the diagnostic challenges and emphasizing the importance of a multidisciplinary approach in managing these rare tumors